A Brief Introduction to the Characteristics of Several Common Spray Drying Equipment
The following combination of one step of the company's several spray drying equipment in the pharmaceutical industry application characteristics, made a brief introduction, can make users have a better understanding, but also a step in the company's products better application and service in the pharmaceutical industry.
3.1LPG high speed centrifugal spray dryer
LPG High Speed Centrifugal Spray Dryers are ideal for the production of powdered, granular or bulk solid products from solutions, emulsions, suspensions and plastic pastes. Therefore, when the finished particle size distribution, residual moisture content, bulk density and particle shape must meet the exact criteria.
The process is as shown in Figure 2, where the air is filtered and heated and dispensed into the drying chamber by the dryer top air distributor. The liquid is sprayed into a very fine mist by a centrifugal atomizer, which is dried in parallel with hot air for a short period of time. The finished product is continuously collected from the bottom of the drying tower and the cyclone, and the exhaust is discharged by the fan.
LPG high-speed centrifugal spray dryer Features:
① drying speed, the material after the atomization of the surface area greatly increased in the hot air flow, the instant can evaporate 95% -98% of the water to complete the drying time only a few seconds, especially for heat-sensitive materials drying.
② products with good uniformity, mobility and solubility, product purity, good quality.
③ production process is simplified, easy to operate and control. For moisture content of 40% -60% of the liquid can be dried into a powder product, dry without grinding and screening, reduce the production process, improve product purity. The product size, bulk density, moisture, can be adjusted by changing the operating conditions, control and management convenience.
LPG high-speed centrifugal spray dryer has been used in Beijing Huafeng Pharmaceutical Co., Ltd., Henan Lingrui Pharmaceutical Co., Ltd., Chinese Academy of Sciences Guangrun Biological Industrial Company, Jilin Weiwei Pharmaceutical Co., Ltd. and Henan Puyang Chinese medicine factory.
 
3.2WPG sterile spray dryer
Figure 3WPG sterile spray dryer aseptic production is the pharmaceutical industry in the production of powder injection equipment, antibiotics such as streptomycin sulfate, kanamycin sulfate, etc., in its production process should use sterile spray drying Manufacturing finished product. In a sterile spray drying system, all materials and air entering the system must be sterilized and filtered. Product collection must also be carried out in the sterile room, the spray with the compressed air also need to be purified before use.
Process flow (Figure 3), the dry air by the initial effect, efficiency, high efficiency three filter purification, heating and material heating and mass transfer material mass transfer, dry after the finished product and hot air separated by the cyclone. The finished product is packed in a sterile chamber cleaning table, and the exhaust is evacuated by a bag filter.
The device uses two fluid air sprayers, simple structure, good air distribution, atomization uniform, can meet the requirements of sterile spray. Spray tower equipped with cleaning device, easy to clean tower wall with powder. Hot air purification selection of early effect, efficiency and efficient three filtration system, so the high quality of air purification, to GMP pharmaceutical production requirements.
3.3ZLG Chinese medicine extract spray dryer
ZLG traditional Chinese medicine extract spray dryer (Figure 4) The machine is fully enclosed, all parts are made of stainless steel, with three purification device, filtered air up to 100,000 requirements. Simplified and top equipped with cooling device, So that the wall temperature of <80 ℃, the material on the tower wall to stay no coking deterioration, increasing the rate of harvest (up to 95%).
Basic principles: Chinese medicine extract High-speed centrifugal spray device is centrifugal spray drying technology in the application of specific materials in the drying, but also the use of high-speed centrifugal atomizer to disperse the material into the mist, with hot air full contact to complete the instant dry, Drying of powdery finished products.
Chinese medicine extract special dryer is the traditional Chinese medicine extract and product extract spray dryer, which solves the material in the original LPG high-speed spray dryer in the traditional Chinese medicine in the following situation: ① material sticky wall, the yield is low; ②, material In the tower wall to stay time to produce coking deterioration; ③ difficult to clean, do not meet the GMP requirements; ④ low yield: LPG-150 spray dryer, the output can only handle 50-60kg / h liquid.
In view of the above situation, our company according to the nature of Chinese medicine extract and process requirements of the design of traditional Chinese medicine extractor dryer, the design of traditional Chinese medicine extract dry granulation process (see Figure 5), dry material color is good, no deterioration, improved Drying equipment using the economic benefits of traditional Chinese medicine extract and LPG high-speed centrifugal spray dryer compared to the following characteristics: ① the use of three air filter cleanliness, reaching 300,000; ② using a cooling device, so that the wall temperature of 80 ℃ , The material on the wall to stay in the filter is not "coking"; ③ the entire volume is the original LPG standard centrifugal spray 3.5 times; ④ use of fast open cleaning device, suitable for multi-species production requirements; ⑤ dust using a wet dust, ⑥ to provide atomizer 2, and the use of frequency control; ⑦ using PLC control, program control system screen display; ⑧ using dry air-tightly closed; ⑦ the use of air-conditioning device, the effect is more satisfactory; delivery.
 
3.4PGL series spray drying granulator
PGL series of B-type / C-type two, PGL-B spray drying granulator set spray drying / fluidization granulation in one, to achieve liquid material one-step granulation; PGL-C spray drying granulator set, spray drying , Granulation, particle coating in one multi-functional.
1) PGL-B spray drying granulator using spray technology, especially for microbial materials, heat-sensitive materials, efficiency than the FL boiling granulator 1-2 times; the final product of up to 0.1% moisture, equipped with powder device, Granulation rate ≥ 95%, can be made 0.2-2mm particles. At the same time, improve the design of the mixed multi-fluid atomizer, can handle the proportion of extract up to 1.3g / cm3.
PGL-B spray drying granulator can be applied to tablets, granules, capsules particles, can also be applied to low-sugar, sugar-free proprietary Chinese medicine particles.
PGL-B spray drying granulator has been in Changzhou Jianmin Pharmaceutical Factory, Chia Taiqing Chunbao Pharmaceutical Co., Ltd., Shanghai Cai Tongde Tong Pharmaceutical Factory, Hunan Jiuzhitang Pharmaceutical Co., Ltd., Hainan Chengcheng Pharmaceutical Co., Ltd., Anhui Phoenix Pine Co., Ltd. Harbin Island Pharmaceutical Co., Ltd. Hebei Pharmaceutical Group Pharmaceutical Co., Ltd. and many other companies use.

2) PGL-C spray drying granulator can be tablets, granules, capsule particles preparation, slow release granule preparation, low sugar, sugar-free, low-dose particles preparation. Preparation of the particles instantly soluble, easy to dissolve granules, easy to disintegrate the tablet, the use of liquid materials as a wetting adhesive, can save a lot of ethanol solvent.
Equipment in the closed negative pressure work, the surface smooth, no dead ends, in line with GMP requirements; the entire dry space temperature uniformity, supporting multi-fluid atomizer, can effectively improve production efficiency and protect product quality; automation has been further improved, simple operation , Can effectively protect the stability of product quality.
 
3.5YPG pressure spray drying granulator
YPG pressure spray drying granulator is the material into the top of the tower at the nozzle of the nozzle into a small droplet droplets, parallel with the top of the hot air to complete the dry. PG pressure spray drying granulator process (such as (Figure 7), the machine has a high dust collection, no sticky wall, energy efficient and so on, especially for heat-sensitive materials such as Chinese medicine extract, medicine glue, yeast, , Antibiotics, amylases, lipases and other dry.
 3.6QPG air spray drier
QPG air spray dryer process (such as Figure 8), clean air into the drying tower, in the tower hot air with two fluid (or three fluid) nozzle will be a variety of liquid material into a small droplets, and hot air Rapid heat exchange, evaporation of liquid in the liquid (or solvent), and with hot air discharge, get powder products.
QPG air spray dryer especially on the sticky, paste, paste material effect is good, other equipment can not be replaced. The product is a variety of experimental species, low temperature drying applications. The nozzle structure is simple, easy maintenance, high operating costs.